Multi-step Flow Synthesis of the Anthelmintic Drug Praziquantel

Abstract Praziquantel (PZQ; Brand name: Biltricide) is categorized as an anthelminthic drug, and it used for the treatment of Schistosomiasis other parasitic infections. The World Health Organization (WHO) has classified one essential emergency medicines needed across globe. price PZQ formulated product depends on associated method preparation, along with cost raw materials. A precise reliable preparation using a flow-chemistry approach described in this study phenylethylamine starting material. main objective present to identify new economical route synthesis that could decrease production time drastically from days minutes be transferred large-scale production. Simultaneously, purity obtained intermediates steps, single or continuous process, determined by HPLC analysis were more than 90% pure. process current was achieved less (ca. 3–4 h) conventional methods days). Moreover, required quantity key intermediate dimethoxyethanamine 40–50% existing methods.